Study of the bioenhancement effect
A comparative study on the relative uptake of Capsaicin, Phenylcapsaicin and Curcumin in single and combination formulations using a Caco-2 invitro cell assay.
The CACO trial shows that the presence of phenylcapsaicin doubled the relative
uptake of curcumin. In addition the study shows that the microencapsulation
also enhances absorption and improves the nutrient uptake.
The presence of Phenylcapsaicin increased the uptake of Curcumin at all three dose levels even as compared to the Capsaicin + Curcumin formulation (P < 0.05) (CACO in vitro study).